A Helping Hand for Cytochrome P450 Enzymes

Cytochrome P450-Mediated Phytoremediation using Transgenic Plants: A Need for Engineered Cytochrome P450 Enzymes

There is an increasing demand for versatile and ubiquitous Cytochrome P450 (CYP) biocatalysts for biotechnology, medicine, and bioremediation. In the last decade there has been an increase in realization of the power of CYP biocatalysts for detoxification of soil and water contaminants using transgenic plants. However, the major limitations of mammalian CYP enzymes are that they require CYP red...

Cytochrome P450 enzymes and tumor therapy.

To the Editors: McFadyen et al. (1) have contributed a review on the aspects of cytochrome P450–related tumor therapy that is worth reading. It clearly shows the potential of such an approach for cancer therapy. Based on my own experience, I would kindly like to point out a few additional issues that may add to the excellent review. Ifosfamide and cyclophosphamide both use some more cytochrome ...

Characterization of human cytochrome P450 enzymes.

Many biochemical approaches have been applied to the human cytochrome P450 enzymes, and more than 20 different gene products have been characterized with regard to their properties and catalytic specificities. The complement of the various cytochrome P450 enzymes in a given individual varies markedly, and dramatic differences may be seen in drug metabolism, pharmacological response, and suscept...

Cytochrome P450 Enzymes in Vascular Homeostasis

Since the initial reports that renal cytochrome P450 (CYP) enzymes can metabolize arachidonic acid to substances which affect arterial tone, it has become increasingly clear that CYP enzymes expressed within the cardiovascular system play a crucial role in the modulation of vascular homeostasis. There is strong evidence suggesting that the activation of a CYP epoxygenase in endothelial cells is...

A helping hand for the invisible hand.